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Additional reading: Chapter 10

Additional Reading:

Churchill, GA.  2016.  Eric Lander and David Botstein on Mapping Quantitative Traits.  Genetics 2013: 1-3. A perspective on the paper introduced in Chapter 9 on using molecular polymorphisms to map genes in humans, with a particular focus on its application to complex traits.

Falconer, DS and TF McKay 1996 Introduction to Quantitative Genetics, 4th edition. Pearson Education Ltd.

Marian AJ. Molecular genetic studies of complex phenotypes. Transl Res. 2012;159(2):64-79. doi: 10.1016/j.trsl.2011.08.001.

 Psychiatric Genomics Consortium, 2005 Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.  The Lancet , Volume 381 , Issue 9875 , 1371 - 1379

Wellcome Trust Case Consortium 2007. Genome-wide association study of 14,000 cases of seven common diseases and 3000 shared controls.  Nature 447: 661-678. Among the earliest and most influential genome-wide association studies, and one of the most complete presentations. 

Additional Reading for Boxes:

Shendure, J and S. Fields, 2016.  Massively parallel genetics.  Genetics 203: 617-619.  Challenges and considerations with identifying disease genes in humans by direct sequencing. 

Barnshad, MJ 2011 Exome sequencing as a tool for Mendelian disease gene discovery.  Nat. Rev. Genetics 12: 745-754

Tenesa, A and CS Haley 2013.  The heritability of human disease: estimation, uses, and abuses.  Nat. Rev. Genetics 14: 139-149