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Movies from real research: Lateral line migration

Overview of lateral line migration in zebrafish

Movie showing in vivo imaging of lateral line migration in zebrafish. For more information see Haas and Gilmour (2006) Chemokine Signaling Mediates Self-Organizing Tissue Migration in the Zebrafish Lateral Line Dev. Cell. 10 5L 673-680. Movie courtesy Darren Gilmour.

 

High-resolution tiled movie of lateral line migration in zebrafish

High-resolution tiled movie of lateral line migration and organ deposition with nuclei counter-labelled (actin labelled with GFP, Nuclei labelled with RFP). Movie courtesy Darren Gilmour.

 

Side view of lateral line migration in zebrafish

Side view of lateral line upon release from FGF inhibitor, showing dynamic basal feet and recovery of epithelial polarity. For more information see Lecaudey et al. (2008) Dynamic Fgf signaling couples morphogenesis and migration in the zebrafish lateral line primordium. Development 135, 2695-2705. Movie courtesy Darren Gilmour.

 

Mitosis during lateral line migration in zebrafish

Mosaic-labelling with the MT binding protein EMTB-GFP. Nicely shows mitoses taking place during migration. For more information see Revenu et. al. (2014) Quantitative cell polarity imaging defines leader-to-follower transitions during collective migration and the key role of microtubule-dependent adherens junction formation. Development 141, 1282-1291. Movie courtesy Darren Gilmour.

 

Mosaic-labelling of lateral line migration in zebrafish

Mosaic-labelling with the actin binding protein LifeAct-GFP in red nuclei labelled primordium, showing that all cells are motile. Movie courtesy Darren Gilmour.

 

Mosaic-labelling of lateral line migration in zebrafish

Mosaic-labelling with the actin binding protein LifeAct-GFP. Movie courtesy Darren Gilmour.