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Introduction: “My Lobotomy”

PART I  Schizophrenia

The Toll of Psychiatric Disorders Is Huge

Schizophrenia Is a Major Neurobiological Challenge in Psychiatry

Schizophrenia is characterized by an unusual array of symptoms

Schizophrenia has a heritable component

RESEARCHERS AT WORK: Stress increases the risk of schizophrenia

An integrative model of schizophrenia emphasizes the interaction of factors

The brains of some people with schizophrenia show structural and functional changes

Antipsychotic medications revolutionized the treatment of schizophrenia

BOX 12.1: Long-Term Effects of Antipsychotic Drugs

PART II  Mood Disorders

Depression Is the Most Prevalent Disorder of Mood

Inheritance is an important determinant of depression

The brain changes with depression

A wide variety of treatments are available for depression

SIGNS & SYMPTOMS: Mixed Feelings about SSRIs

Why do more females than males suffer from depression?

Sleep characteristics change in affective disorders

Scientists are still searching for animal models of depression

In Bipolar Disorder, Mood Cycles between Extremes

RESEARCHERS AT WORK: The entirely accidental discovery of lithium therapy

PART III  Anxiety Disorders

There Are Several Types of Anxiety Disorders

Drug treatments provide clues to the mechanisms of anxiety

In Post-Traumatic Stress Disorder, Horrible Memories Won’t Go Away

In Obsessive-Compulsive Disorder, Thoughts and Acts Keep Repeating

BOX 12.2: Tics, Twitches, and Snorts: The Unusual Character of Tourette’s Syndrome