Chapter 5 Further reading

Methods in protein investigation

• Minor, D.L. Jr (2007). The neurobiologist’s guide to structural biology: A primer on why macromolecular structure matters and how to evaluate structural data. Neuron, 54, 511–33.

A review of the methodology of protein structure determination, and the value of structural knowledge, for a scientifically literate non-specialist audience.

• Nobelprize.org. (2002) The 2002 Nobel Prize in Chemistry—Advanced Information. www.nobelprize.org/nobel_prizes/chemistry/laureates/2002/advanced.html

Explains the science and significance of the development of mass spectrometry and NMR for identification and structure analyses of biological macromolecules by the recipients of the Nobel Prize in Chemistry, John B. Fenn, Koichi Tanaka, and Kurt Wüthrich.

• Cravatt, B.F., Simon, G.M., and Yates, J. R. III (2007). The biological impact of mass-spectrometry-based proteomics. Nature, 450, 991–1000.

Gives an overview of MS proteomic techniques, and then gives examples of how they have been used to increase understanding of biological pathways and processes, often with the potential for medical applications. Several of the examples refer to processes covered later on in this book. 

Back to top