Chapter 18 Chapter Outline

Intermediate and Lateral Plate Mesoderm: Heart, Blood, and Kidneys

Intermediate Mesoderm: The Kidney

Specification of the Intermediate Mesoderm: Pax2, Pax8, and Lim1

Reciprocal Interactions of Developing Kidney Tissues

  • Mechanisms of reciprocal induction

Lateral Plate Mesoderm: Heart and Circulatory System

Heart Development

  • A minimalist heart
  • Formation of the heart fields
  • Specification of the cardiogenic mesoderm
  • Migration of the cardiac precursor cells
  • Initial heart cell differentiation
  • Looping of the heart

Blood Vessel Formation

  • Vasculogenesis: The initial formation of blood vessels
  • Angiogenesis: Sprouting of blood vessels and remodeling of vascular beds

Hematopoiesis: Stem Cells and Long-Lived Progenitor Cells

  • Sites of hematopoiesis
  • The bone marrow HSC niche

Coda

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