Alvarez, I. S. and G. C. Schoenwolf. 1992. Expansion of surface epithelium provides the major extrinsic force for bending of the neural plate. J. Exp. Zool. 261: 340–348.
Anderson, D. D., C. F. Woeller, E. P. Chiang, B. Shane and P. J. Stover. 2012. Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis. J. Biol. Chem. 287: 7051–7062.
Archer, T. C., J. Jin and E. S. Casey. 2011. Interaction of Sox1, Sox2, Sox3 and Oct4 during primary neurogenesis. Dev. Biol. 350: 429–40.
Artama, M., A. Auvinen, T. Raudaskoski, I. Isojärvi, and J. Isojärvi. 2005. Antiepileptic drug use of women with epilepsy and congenital malformations in offspring. Neurology 64: 1874–1878.
Balaskas, N., A. Ribeiro, J. Panovska, E. Dessaud, N. Sasai, K. M. Page, J. Briscoe and V. Ribes. 2012. Gene regulatory logic for reading the Sonic Hedgehog signaling gradient in the vertebrate neural tube. Cell 148: 273–284.
Balinsky, B. I. 1975. Introduction to Embryology, 4th Ed. Saunders, Philadelphia, PA.
Bassuk, A. G. and Z. Kibar. 2009. Genetic basis of neural tube defects. Semin. Pediatr. Neurol. 16: 101–110.
Briscoe, J. and S. Small. 2015. Morphogen rules: Design principles of gradient-mediated embryo patterning. Development 142: 3996–4009.
Briscoe, J., L. Sussel, P. Serup, D. Hartigan-O’Connor, T. M. Jessell, J. L. R. Rubenstein and J. Ericson. 1999. Homeobox gene Nkx2.2 and specification of neuronal identity by graded Sonic hedgehog signaling. Nature 398: 622–627.
Bu, P., Y. A. Evrard, G. Lozano, and S. Y. R. Dent. 2007. Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos. Mol. Cell. Biol. 27: 3405–3416.
Cambray, N. and V. Wilson. 2007. Two distinct sources for a population of maturing axial progenitors. Development 134: 2829–2840.
Catala, M., M.-A. Teillet and N. M. Le Douarin. 1995. Organization and development of the tailbud analyzed with the quail-chick chimaera system. Mech. Dev. 51: 51–65.
Catala, M., M.-A. Teillet, E. M. De Robertis and N. M. Le Douarin. 1996. A spinal cord fate map in the avian embryo: While regressing, Hensen’s node lays down the notochord and floor plate thus joining the spinal cord lateral walls. Development 122: 2599–2610.
Catela, C., M. M. Shin, and J. S. Dasen. 2015. Assembly and function of spinal circuits for motor control. Annu. Rev. Cell Dev. Biol. 31: 669–698.
Centers for Disease Control. 1992. Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects. Morb. Mortal. Wkly. Rep. 41: 1–7.
Chapman, D. L. and V. E. Papaioannou. 1998. Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6. Nature 391: 695–697.
Chiang, C., Y. Litingtung, E. Lee, K. E. Young, J. L. Cordoen, H. Westphal and P. A. Beachy. 1996. Cyclopia and axial patterning in mice lacking sonic hedgehog gene function. Nature 383: 407–413.
Cohen, M., A. Kicheva, A. Ribeiro, R. Blassberg, K. M. Page, C. P. Barnes, and J. Briscoe. 2015. Ptch1 and Gli regulate Shh signalling dynamics via multiple mechanisms. Nat. Commun. 6: 6709.
Copp, A. J., N. D. E. Greene and J. N. Murdoch. 2003. The genetic basis of mammalian neurulation. Nat. Rev. Genet. 4: 784–93.
Czeizel, A. E. and I. Dudás. 1992. Prevention of first occurrence of neural tube defects by periconceptional vitamin supplementation. N. Engl. J. Med. 327: 1832–1835.
Dady, A., E. Havis, V. Escriou, M. Catala, and J. L. Duband. 2014. Junctional neurulation: a unique developmental program shaping a discrete region of the spinal cord highly susceptible to neural tube defects. J. Neurosci. 34: 13208–13221.
Dessaud, E., L. L. Yang, K. Hill, B. Cox, F. Ulloa, A. Ribeiro, A. Mynett, B. G. Novitch and J. Briscoe. 2007. Interpretation of the Sonic hedgehog morphogen gradient by a temporal adaptation mechanism. Nature 450: 717–720.
Detrick, R. J., D. Dickey and C. R. Kintner. 1990. The effects of N-cadherin misexpression on morphogenesis in Xenopus embryos. Neuron 4: 493–506.
Echelard, Y., D. J. Epstein, B. St.-Jacques, L. Shen, J. Mohler, J. A. McMahon and A. McMahon. 1993. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 75: 1417–1430.
Eom, D. S., S. Amarnath, J. L. Fogel, and S. Agarwala. 2011. Bone morphogenetic proteins regulate neural tube closure by interacting with the apicobasal polarity pathway. Development 138: 3179–3188.
Eom, D. S., S. Amarnath, J. L. Fogel, and S. Agarwala. 2012. Bone morphogenetic proteins regulate hinge point formation during neural tube closure by dynamic modulation of apicobasal polarity. Birth Defects Res. A: Clin. Mol. Teratol. 94: 804–816.
Eom, D. S., S. Amarnath, and S. Agarwala. 2013. Apicobasal polarity and neural tube closure. Dev. Growth Differ. 55: 164–172.
Feil, R., R. A. Waterland, M. F. Fraga, and R. L. Jirtle. 2012. Epigenetics and the environment: Emerging patterns and implications. Nat. Rev. Genet. 13: 97–109.
Fournier-Thibault, C., C. Blavet, A. Jarov, F. Bajanca, S. Thorsteinsdóttir and J. L. Duband. 2009. Sonic hedgehog regulates integrin activity, cadherin contacts, and cell polarity to orchestrate neural tube morphogenesis. J. Neurosci. 29: 12506–12520.
Fujimori, T., S. Miyatani and M. Takeichi. 1990. Ectopic expression of N-cadherin perturbs histogenesis in Xenopus embryos. Development 110: 97–104.
Gallera, J. 1971. Primary induction in birds. Adv. Morphogenet. 9: 149–180.
Gont, L. K., H. Steinbeisser, B. Blumberg and E. M. De Robertis. 1993. Tail formation as a continuation of gastrulation: The multiple cell populations of the Xenopus tailbud derive from the late blastopore lip. Development 119: 991–1004.
Gouti, M., V. Metzis, and J. Briscoe. 2015. The route to spinal cord cell types: A tale of signals and switches. Trends Genet. 31: 282–289.
Guthrie, S. and A. Lumsden. 1991. Formation and regeneration of rhombomere boundaries in the developing chick hindbrain. Development 112: 221–229.
Handrigan, G. R. 2003. Concordia discors: Duality in the origin of the vertebrate tail. J. Anat. 202: 255–67.
Harland, R. 2000. Neural induction. Curr. Opin. Genet. Dev. 10: 357–362.
Harrington, M. J., E. Hong and R. Brewster. 2009. Comparative analysis of neurulation: First impressions do not count. Mol. Reprod. Dev. 76: 954–965.
Harris, M. J. and D. M. Juriloff. 2010. An update to the list of mouse mutants with neural tube closure defects and advances toward a complete genetic perspective of neural tube closure. Birth Defects Res. A: Clin. Mol. Teratol. 88: 653–669.
Hashimoto, H., F. B. Robin, K. M. Sherrard, and E. M. Munro. 2015. Sequential contraction and exchange of apical junctions drives zippering and neural tube closure in a simple chordate. Dev. Cell. 32: 241–255.
Henrique, D., E. Abranches, L. Verrier and K. G. Storey. 2015. Neuromesodermal progenitors and the making of the spinal cord. Development 142: 2864–2875.
Jacobson, A. G. and J. G. Moury. 1995. Tissue boundaries and cell behavior during neurulation. Dev. Biol. 171: 98–110.
Jessell, T. M. 2000. Neuronal specification in the spinal cord: Inductive signals and transcriptional codes. Nat. Rev. Genet. 1: 20–29.
Lawson, A., H. Anderson and G. C. Schoenwolf. 2001. Cellular mechanisms of neural fold formation and morphogenesis in the chick embryo. Anat. Rec. 262: 153–168.
Lee, S.-K. and S. L. Pfaff. 2001. Transcriptional networks regulating neuronal identity in the developing spinal cord. Nat. Neurosci. Suppl. 4: 1183–1191.
Lele, Z., A. Folchert, M. Concha, G. J. Rauch, R. Geisler, F. Rosa, S. W. Wilson, M. Hammerschmidt and L. Bally-Cuif. 2002. Parachute/N-cadherin is required for morphogenesis and maintained integrity of the zebrafish neural tube. Development 129: 3281–3294.
Li, H., J. Zhang and L. Niswander. 2018. Zinc deficiency causes neural tube defects through attenuation of p53 ubiquitylation. Development 145: dev169797.
Liem, K. F., Jr., G. Tremml, H. Roelink and T. M. Jessell. 1995. Dorsal differentiation of neural plate cells induced by BMP-mediated signals from epidermal ectoderm. Cell 82: 969–979.
Liem, K. F., Jr., G. Tremml and T. M. Jessell. 1997. A role for the roof plate and its resident TGF-b-related proteins in neuronal patterning in the dorsal spinal cord. Cell 91: 127–138.
Liem, K. F., Jr., T. M. Jessell and J. Briscoe. 2000. Regulation of the neural patterning activity of Sonic hedgehog by secreted BMP inhibitors expressed by notochord and somites. Development 127: 4855–4866.
Lowery, L. A. and H. Sive. 2004. Strategies of neurulation and a re-evaluation of teleost neural tube formation. Mech. Dev. 121: 1189–1197.
Lumsden, A. 2004. Segmentation and compartition in the early avian hindbrain. Mech. Dev. 121: 1081–1088.
Lumsden, A. and R. Keynes. 1989. Segmental patterns of neuronal development in the chick hindbrain. Nature 337: 424–428.
Massarwa, R. and L. Niswander. 2013. In toto live imaging of mouse morphogenesis and new insights into neural tube closure. Development 140: 226–236.
McShane, S. G., M. A. Molè, D. Savery, N. D. Greene, P. P. Tam, and A. J. Copp. 2015. Cellular basis of neuroepithelial bending during mouse spinal neural tube closure. Dev. Biol. 404: 113–124.
Milunsky, A., H. Jick, S. S. Jick, C. L. Bruell, D. S. Maclaughlen, K. J. Rothman and W. Willett. 1989. Multivitamin folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects. J. Am. Med. Assoc. 262: 2847–2852.
Moore, K. L. and T. V. N. Persaud. 1993. Before We Are Born: Essentials of Embryology and Birth Defects. W. B. Saunders, Philadelphia, PA.
Moury, J. D. and G. C. Schoenwolf. 1995. Cooperative model of epithelial shaping and bending during avian neurulation: Autonomous movements of the neural plate, autonomous movements of the epidermis, and interactions in the neural plate/epidermis transition zone. Dev. Dyn. 204: 323–337.
Muhr, J., E. Andersson, M. Persson, T. M. Jessell and J. Ericson. 2001. Groucho-mediated transcriptional repression establishes progenitor cell pattern and neuronal fate in the ventral spinal cord. Cell 104: 861–873.
Murko, C., S. Lagger, M. Steiner, C. Seiser, C. Schoefer, and O. Pusch. 2013. Histone deacetylase inhibitor trichostatin A induces neural tube defects and promotes neural crest specification in the chicken neural tube. Differentiation 85: 55–66.
Nakatsu, T., C. Uwabe and K. Shiota. 2000. Neural tube closure in humans initiates at multiple sites: Evidence from human embryos and implications for the pathogenesis of neural tube defects. Anat. Embryol. 201: 455–466.
Nguyen, V. H., J. Trout, S. A. Connors, P. Andermann, E. Weinberg and M. C. Mullins. 2000. Dorsal and intermediate neuronal cell types of the spinal cord are established by a BMP signaling pathway. Development 127:1209–1220.
Nicol, D. and I. A. Meinertzhagen. 1988a. Development of the central nervous system of the larva of the ascidian Ciona intestinalis L. I. The early lineages of the neural plate. Dev. Biol. 130: 721–736.
Nicol, D. and I. A. Meinertzhagen. 1988b. Development of the central nervous system of the larva of the ascidian Ciona intestinalis L. II. Neural plate morphogenesis and cell lineages during neurulation. Dev. Biol. 130: 737–766.
Nievelstein, R. A. J., N. G. Hartwig, C. Vermeij-Keers and J. Valk. 1993. Embryonic development of the mammalian caudal neural tube. Teratology 48: 21–31.
Niwa, M. and 10 others. 2013. Adolescent stress-induced epigenetic control of dopaminergic neurons via glucocorticoids. Science 339: 335–339.
O’Rahilly, R. and F. Müller. 2002. The two sites of fusion of the neural folds and the two neuropores of the human embryo. Teratology 65: 162–170.
Pasteels, J. 1937. Etudes sur la gastrulation des vertébrés méroblastiques. III. Oiseaux. IV. Conclusions générales. Arch. Biol. 48: 381–488.
Patten, B. M. 1971. Early Embryology of the Chick, 5th Ed. McGraw-Hill, New York.
Placzek, M., M. Tessier-Lavigne, T. Yamada, T. Jessell and J. Dodd. 1990. Mesodermal control of neural cell identity: Floor plate induction by the notochord. Science 250: 985–988.
Pyrgaki, C., P. Trainor, A. K. Hadjantonakis and L. Niswander. 2010. Dynamic imaging of mammalian neural tube closure. Dev. Biol. 344: 941–947.
Pyrgaki, C., A. Liu, and L. Niswander. 2011. Grainyhead-like 2 regulates neural tube closure and adhesion molecule expression during neural fold fusion. Dev. Biol. 353: 38–49.
Rifat, Y., V. Parekh, T. Wilanowski, N. R. Hislop, A. Auden, S. B. Ting, J. M. Cunningham and S. M. Jane. 2010. Regional neural tube closure defined by the Grainy head-like transcription factors. Dev. Biol. 345: 237–245.
Roelink, H., J. A. Porter, C. Chiang, Y. Tanabe, D. T. Chang, P. A. Beachy and T. M. Jessell. 1995. Floor plate and motor neuron induction by different concentrations of amino-terminal cleavage product of Sonic hedgehog autoproteolysis. Cell 81: 445–455.
Saitsu, H., S. Yamada, C. Uwabe, M. Ishibashi and K. Shiota. 2007. Aberrant differentiation of the axially condensed tail bud mesenchyme in human embryos with lumbosacral myeloschisis. Anat. Rec. 290: 251–258.
Sasai, N., E. Kutejova, and J. Briscoe. 2014. Integration of signals along orthogonal axes of the vertebrate neural tube controls progenitor competence and increases cell diversity. PLOS Biol. 12: e1001907.
Sausedo, R. A., J. L. Smith and G. C. Schoenwolf. 1997. Role of oriented cell division in shaping and bending of the neural plate. J. Comp. Neurol. 381: 473–488.
Schoenwolf, G. C. 1984. Histological and ultrastructural studies of secondary neurulation in mouse embryos. Am. J. Anat. 169: 361–376.
Schoenwolf, G. C. 1991a. Cell movements driving neurulation in avian embryos. Development 2: 157–168.
Schoenwolf, G. C. 1991b. Cell movements in the epiblast during gastrulation and neurulation in avian embryos. In R. Keller et al. (eds)., Gastrulation. Plenum, New York, 1–28.
Schoenwolf, G. C. and J. Delongo. 1980. Ultrastructure of secondary neurulation in the chick embryo. Am. J. Anat. 158: 43–63.
Schoenwolf, G. C. and M. V. Franks. 1984. Quantitative analyses of changes in cell shapes during bending of the avian neural plate. Dev. Biol. 105: 257–272.
Schoenwolf, G. C. and J. L. Smith. 1990. Epithelial cell wedging: A fundamental cell behavior contributing to hinge point formation during epithelial morphogenesis. In R. E. Keller and D. Fristrom (eds.). Control of Morphogenesis, Vol. 1. Saunders, London, 325–334.
Shimokita, E., I. Kashin and Y. Takahashi. 2010. Secondary neurulation: A novel model to study tubulogenesis. Poster presentation.
Shpargel, K. B., T. Sengoku, S. Yokoyama, and T. Magnuson. 2012. UTX and UTY demonstrate histone demethylase-independent function in mouse embryonic development. PLOS Genet. 8: e1002964.
Shyamasundar, S., S. P. Jadhav, B. H. Bay, S. S. W. Tay, S. D. Kumar, D. Rangasamy, and S. T. Thameem Dheen. 2013. Analysis of epigenetic factors in mouse embryonic neural stem cells exposed to hyperglycemia. PLOS ONE 8: e65945.
Smith, J. L. and G. C. Schoenwolf. 1987. Cell cycle and neuroepithelial cell shape during bending of the chick neural plate. Anat. Rec. 218: 196–206.
Smith, J. L. and G. C. Schoenwolf. 1988. Role of cell cycle in regulating neuroepithelial cell shape during bending of the chick neural plate. Cell Tissue Res. 252: 491–500.
Smith, J. L. and G. C. Schoenwolf. 1989. Notochordal induction of cell wedging in the chick neural plate and its role in neural tube formation. J. Exp. Zool. 250: 49–62.
Smith, J. L. and G. C. Schoenwolf. 1991. Further evidence of extrinsic forces in bending of the neural plate. J. Comp. Neurol. 307: 225–236.
Smith, J. L. and G. C. Schoenwolf. 1997. Neurulation: Coming to closure. Trends Neurosci. 20: 510–517.
Stern, C. D. 2005. Neural induction: Old problem, new findings, yet more questions. Development 132: 2007–2021.
Steventon, B. and A. Martinez Arias. 2017. Evo-engineering and the cellular and molecular origins of the vertebrate spinal cord. Dev. Biol. 432: 3–13.
Stottmann, R. W., M. Berrong, K. Matta, M. Choi, and J. Klingensmith. 2006. The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms. Dev. Biol. 295: 647–663.
Takemoto, T., M. Uchikawa, M. Yoshida, D. M. Bell, R. Lovell-Badge, V. E. Papaioannou and H. Kondoh. 2011. Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells. Nature 470: 394–398.
Tye, K. M. and 12 others. 2013. Dopamine neurons modulate neural encoding and expression of depression-related behaviour. Nature 493: 537–541.
Tzouanacou, E., A. Wegener, F. J. Wymeersch, V. Wilson and J. F. Nicolas. 2009. Defining the progression of lineage segregations during mammalian embryogenesis by clonal analysis. Dev. Cell 17: 365–376.
van Straaten, H. W. M., J. W. M. Hekking, E. J. L. M. Wiertz-Hoessels, F. Thors and J. Drukker. 1988. Effect of the notochord on the differentiation of a floor plate area in the neural tube of the chick embryo. Anat. Embryol. 177: 317–324.
Welstead, G. G., M. P. Creyghton, S. Bilodeau, A. W. Cheng, S. Markoulaki, R. A. Young, and R. Jaenisch. 2012. X-linked H3K27me3 demethylase Utx is required for embryonic development in a sex-specific manner. Proc. Natl. Acad. Sci. 109: 13004–13009.
Werth, M. and 13 others. 2010. The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex. Development 137: 3835–3845.
Wilde, J. J., J. R. Petersen, and L. Niswander. 2014. Genetic, epigenetic, and environmental contributions to neural tube closure. Annu. Rev. Genet. 48: 583–611.
Wilson, S. I. and T. Edlund. 2001. Neural induction: Toward a unifying mechanism. Nat. Neurosci. 4: 1161–1168.
Wilson, V., I. Olivera-Martinez and K. G. Storey. 2009. Stem cells, signals and vertebrate body axis extension. Development 136: 1591–1604.
Xiong, F. and 11 others. 2013. Specified neural progenitors sort to form sharp domains after noisy Shh signaling. Cell 153: 550-561.
Ybot-Gonzalez, P., P. Cogram, D. Gerrelli, and A. J. Copp. 2002. Sonic hedgehog and the molecular regulation of mouse neural tube closure. Development 129: 2507–2517.
Ybot-Gonzalez, P., C. Gaston-Massuet, G. Girdler, J. Klingensmith, R. Arkell, N. D. E. Greene, and A. J. Copp. 2007. Neural plate morphogenesis during mouse neurulation is regulated by antagonism of BMP signalling. Development 134: 3203–3211.