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Further Development 7.1 The Origins of Fertilization Research

Fertilization: Beginning a New Organism

7.1.1. Early History of Fertilization

7.1.2. The Mechanism of Fertilization

– F. R. Lillie, 1913 Science 38 (1913): 524-528.

In this classic paper, Lillie predicts the nature of cell surface receptors and their activation by the binding of ligands on their extracellular domains.

7.1.3. On the Nature of the Process of Fertilization and the Artificial Production of Normal Larvae (Plutei) from the Unfertilized Eggs of the Sea Urchin

– Jacques Loeb, 1899 and the Artificial Production of Normal Larvae (Plutei) from the Unfertilized Eggs of the Sea Urchin

In this paper, Loeb emphasizes the roles of ions in initiating early development.